2016- : Committee member, The Chinese Society of Toxicology

Research Interests

Molecular Toxicology

Academic Projects

1. Jan.2017-Dec.2019, Principle Investigator, Epithelial-mesenchymal transition involved in pulmonary fibrosis induced by nano NiO via TGF-β1 signaling pathway, the National Natural Science Foundation of China

2. Jan.2016-Dec.2018, Principle Investigator, Technology research of rural water infectious disease prevention and control in Lanzhou city, the Science and Technology Bureau in Lanzhou city

3. Jun.2017-May.2019, Principle Investigator, Treatment effect of curcumin on chemical liver injury, the Science and Technology Bureau in Chengguan District

4. Jan.2017-Dec.2018, Principle Investigator, Role of TGF-β1/Smads/MAPK pathway in lung fibers induced by nano NiO, the Fundamental Research Funds for the Central Universities

5. Jan.2015-Dec.2016, Principle Investigator, Effect of lung toxicity induced by nano NiO in Rats, the Fundamental Research Funds for the Central Universities

Representative Achievements

1. Xuhong Chang, Hongjun Zhao, Jinxia Gao, Lijuan chen, An Zhu, Cheng Wang, Shu Yu, Xiaolan Ren, Pengfei Ge, Yingbiao Sun. Pulmonary toxicity of exposure to nano nickel oxide. Micro & Nano Letters. 2018, 13(6): 733-738.

2. Minmin Tian, Fangfang Liu, Han Liu, Qiong Zhang, Lei Li, Xiangbo Hou, Jianxin Zhao, Sheng Li, Xuhong Chang, Yingbiao Sun. GSPE attenuates Cis-induced oxidative stress and testosterone synthase inhibition in rat testes. Syst Biol Repro Med. 2018, 290(3): 246-259.（Corresponding author）

3. Shu Yu, Fangfang Liu, Chen Wang, Jinyi Zhang, An Zhu, Lingyue Zou, Aijie Han, Jin Li, Xuhong Chang, Yingbiao Sun. Role of oxidative stress in liver toxicity induced by nickel oxide nanoparticles in rats. Mol Med Rep. 2018, 17(1): 3133-3139. （Corresponding author）

4. Chang Xuhong, Liu Fangfang, Tian Minmin, Hongjun Zhao, Aijie Han, Yingbiao Sun. Nickel oxide nanoparticles induce hepatocyte apoptosis via activating endoplasmic reticulum stress pathways in rats. Environ Toxicol. 2017, 32(12): 2492-2499.

5. Xuhong Chang, An Zhu, Fangfang Liu, Lingyue Zou, Li Su, Sheng Li, Yingbiao Sun. Role of NF-κB Activation and Th1/Th2 Imbalance in Pulmonary Toxicity Induced by Nano NiO. Environ Toxicol. 2017, 32(4): 1354-1362.

6. Xuhong Chang, An Zhu, Fangfang Liu, Lingyue Zou, Li Su, Shaokun Liu, Honghua Zhou, Yanyan Sun, Aijie Han, Yifan Sun, Sheng Li, Jin Li, Yingbiao Sun. Nickel oxide nanoparticles induced pulmonary fibrosis via TGF-beta1 activation in rats. Hum Exp Toxicol. 2017, 36(8): 802-812.

7. Fangfang Liu, Xuhong Chang, Minmin Tian, An Zhu, Lingyue Zou, Aijie Han, Li Su, Sheng Li, Yingbiao Sun. Nano NiO induced liver toxicity via activating the NF-κB signaling pathway in rats. Toxicol Res. 2017, 6(2): 242-250.

8. An Zhu, Xuhong Chang, Yingbiao Sun, Lingyue Zou, Li Su, Yifan Sun, Sheng Li, Shaokun Liu, Yanyan Sun, Honghua Zhou, Jin Li. Role of oxidative stress and inflammatory response in subchronic pulmonary toxicity induced by nano nickel oxide in rats. J Nanosci Nanotechno. 2017, 17(3): 1753-1761.

9. Xuhong Chang, Yanxin Xie, Jianru Wu, Meng Tang, Bei Wang. Toxicological characteristics of titanium dioxide nanoparticles in rats. J Nanosci Nanotechno. 2015, 15(2): 1135-1142.

10. Xuhong Chang, Liangjia Zhou, Meng Tang, Bei Wang. Association of fine particles with respiratory disease mortality: A meta-analysis. Arch Environ Occup H. 2015, 70(2): 98-101.

11. Xuhong Chang, Yanyun Fu, Yingjian Zhang, Meng Tang, Bei Wang. Effects of Th1 and Th2 cells balance in pulmonary injury induced by nano titanium dioxide. Environ toxicol phar. 2014, 37(1): 275-283.

12. Xuhong Chang, Yu Zhang, Meng Tang, Bei Wang. Health effects of exposure to nano-TiO2:A meta-analysis of experimental studies. Nanoscale Res Lett. 2013, 8(1): 1-8.

13. Yanyun Fu, Yanqiu Zhang, Xuhong Chang, Yingjian Zhang, Shumei Ma, Jing Sui, Lihong Yin, Yuepu Pu, Geyu Liang. Systemic immune effects of titanium dioxide nanoparticles after repeated intratracheal instillation in rat. Inter J Molecu Sci. 2014, 15(4): 6961-6973.

14. Han Aijie, Zou Lingyue, Gan Xiaoqin, Li Yu, Liu Fangfang, Chang Xuhong, Zhang Xiaotian, Tian Minmin, Li Sheng, Su Li, Sun Yingbiao. ROS generation and MAPKs activation contribute to the Ni-induced testosterone synthesis disturbance in rat Leydig cells. Toxicol Lett. 2018, 290: 36-45.

15. Lingyue Zou, Li Su, Yifan Sun, Aijie Han, Xuhong Chang, An Zhu, Fangfang Liu, Jin Li, Yingbiao Sun. Nickel sulfate induced apoptosis via activating ROS-dependent mitochondria and endoplasmic reticulum stress pathways in rat Leydig cells. Environ Toxicol. 2017, 32(7): 1918-1926.