Xiaoxia Wang,D.V.M., Ph.D.Associate Prof.

Tel.: 13519654530

E-mail: wangxiaoxia@lzu.edu.cn

Education

2002.09-2006.07 Northwest A&F University, Bachelor-Veterinary Medicine 

2006.09-2009.06 Northwest A&F University, Master-Preventive Veterinary Medicine

2009.09-2014.02 University of Manitoba, Ph.D.-Medical Microbiology

Employment

2014.07-present School of Public Health, Lanzhou University, Associate Professor

Honors & Awards

2017.05 The third prize in the 4th Young teacher’s Lecture Competition in Faculty of Medicine, Lanzhou University

2017.04 The third prize in the 3rd Young teacher’s Lecture Competition in School of Public Health, Lanzhou University

2015.05 The third prize in the 2nd Young teacher’s Lecture Competition in School of Public Health, Lanzhou University

2009-2013 Doctoral Research Award, China Scholarship Council

2012.03 Office of AIDS Research Scholarship, Keystone Symposia: Frontiers in HIV Pathogenesis, Therapy and Eradication

2012.06 Dean of Graduate Studies Poster Award, Canadian Student Health Research Forum

2011.10 The 7th Annual Child Health Research Day Poster Award, Manitoba Institute of Child Health

Teaching Courses

Sanitary Microbiology,

Medical Microbiology

Professional Service

Member of Chinese Nutrition Society

Research Interests

Our laboratory studies the molecular and cellular biology of host-pathogen interactions, mainly focused on the mechanisms of epigenetic regulation of viral replication, including HIV-1 latent infection. The primary goal of our studies is to elucidate both the pathogen and host cell-specific mechanisms involved in the growth and spread of HIV-1 and pathogenic zoonotic viruses.

Academic Projects

2016/01-2018/12 National Natural Science Foundation of China (grant no. 81501734),

2015/07-2016/12 The Fun­damental Research Funds for Central Universities (lzujbky-2015-260)

2015/01-2016/06 The Fun­damental Research Funds for Central Universities (lzujbky-2015-185)

Representative Achievements

1. Xiangxiang Qin, Lei Chen, Xiaoning Liu, Shuilin Zheng and Xiaoxia Wang*. Factors affecting body mass index in overweight/obese university students, Gansu, China: a cross sectional study. Southeast Asian J Trop Med Public Health, 2018, 49(4):685-695.(Corresponding author)

2. Xiaole Wei, Xiaoxia Wang*, Huaijie Jia, Zhizhong Jing, Yongxiang Wang, Jiying Tan*. The expression and characterization of DNA demethylation mediated by apolipoprotein B mRNA editing enzyme catalyzes subgroup 3A. Journal of Lanzhou University (Medical Sciences), 2018, 44(03):8-15.(Corresponding author, article in Chinese)

3. Xiangxiang Qin, Xiaoxia Wang*, Lei Chen, and Shuilin Zheng. Impact of diet on the gut microbiota: Research advance. Chinese Journal of Microecology, 2017, 29(12):1480-1482+1489(Corresponding author, article in Chinese)

4. Huaijie Jia, Leilei Zhan, Xiaoxia Wang, Xiaobing He, Guohua Chen, Yu Zhang, Yuan Feng, Yaxun Wei, Yi Zhang, Zhizhong Jing*. Transcriptome analysis of sheep oral mucosa response to Orf virus infection. PLOS ONE, 2017, Oct. 26:1-14.

5. Wenyu Cheng, Huaijie Jia, Xiaobing He, Guohua Chen, Yuan Feng, Chunyan Wang, Xiaoxia Wang and Zhizhong Jing*. Comparison of host gene expression profiles in spleen tissues of genetically susceptible and resistant mice during ECTV infection. BioMed Research International, 2017, doi:10.1155/2017/6456180.

6. Zhujun Ao, Jing Huang, Xiaoli Tan, Xiaoxia Wang, Tian Tian, Xu Zhang, Qingjian Ouyang, Xiaojian Yao*. Characterization of the single cycle replication of HIV-1 expressing Gaussia luciferase in human PBMCs, macrophages, and in CD4+ T cell-grafted nude mouse. Journal of Virological Methods. 2016, 228:95-102.

7. Danappa Jayappa Kallesh, Zhujun Ao, Xiaoxia Wang, Andrew J Mouland, Sudhanshu Shekhar, Xi Yang, Xiaojian Yao*. Human Immunodeficiency Virus Type 1 employs the cellular dynein light chain 1 protein for reverse transcription through interaction with its integrase protein. J Virol. 2015, Apr; 89(7): 3497-511.

8. Xiaoxia Wang, Zhujun Ao, Kallesh Danappa Jayappa, Bei Shi, Gary Kobinger and Xiaojian Yao*. R88-APOBEC3Gm inhibits the replication of both drug-resistant strains of HIV-1 and viruses produced from latently infected cells. Molecular Therapy-Nucleic Acids. 2014, 3, e151.

9. Jinyu Peng, Zhujun Ao, Chris  Matthews, Xiaoxia Wang, Sue  Ramdahin, Xi Chen, Junhua Li, Liyu  Chen, Jianmei He, Blake  Ball, Keith Fowke, Frank  Plummer, Joanne  Embree, Xiaojian Yao*. A naturally occurring Vif mutant (I107T) attenuates anti-APOBEC3G activity and HIV-1 replication. Journal of Molecular Biology, 2013 Aug 23; 425(16):2840-52.

10.Xiaoxia Wang, Zhujun Ao, Liyu Chen, Gary Kobinger, Jinyu Peng and Xiaojian Yao*. The cellular antiviral protein APOBEC3G interacts with HIV-1 reverse transcriptase and inhibits its function during viral replication. J Virol. 2012, Apr; 86(7):3777-86.

11.Tao Zhou, Huaijie Jia, Guohua Chen, Xiaobing He, Yongxiang Fang, Xiaoxia Wang, Qisai Guan, Shuang Zeng, Qing Cui and Zhizhong Jing*. Phylogenetic analysis of Chinese sheeppox and goatpox virus isolates. Virol J. 2012 Jan 20, 9:25.

12.Zhujun Ao, Kallesh Danappa Jayappa, Binchen Wang, Yingfeng Zheng, Xiaoxia Wang, Jinyu Peng, and Xiaojian Yao*. Contribution of host nucleoporin 62 in HIV-1 integrase chromatin association and viral DNA integration. J Biol Chem. 2012, Mar 23; 287(13):10544-55.

13.Zhujun Ao, Xiaoxia Wang, Alexander Bello, Kallesh Danappa Jayappa, Zhe Yu, Keith Fowke, Xinying He, Xi Chen, Junhua Li, Gary Kobinger, and Xiaojian Yao*. Characterization of anti-HIV activity mediated by R88-Apobec3G mutant fusion proteins in CD4+ T cells, PBMCs and macrophages. Human Gene Therapy, 2011 Oct; 22(10):1225-37.