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Xueyan Gu, Ph.D.,Assistant
Tel.: +86 0931 8911745
E-mail: guxy@lzu.edu.cn
Education
2011/09-2018/06, Lanzhou University, School of Life Sciences, Zoology, Ph.D.
2007/09-2011/06, Lanzhou University, School of Life Sciences, Biotechnology, B.S.
Employment
2018/07- Assistant, Institute of Toxicology, School of Public Health, Lanzhou University
Honors & Awards
2018, Excellent Graduate of Lanzhou University
2016, National Scholarship for Doctoral Students
2016, Merit Graduate Students of School of Life Sciences, Lanzhou University
2016, First Prize in Academic Paper Presentation, School of Life Sciences, Lanzhou University
2009-2016, Academic Scholarship of Lanzhou University
Teaching Courses
Teaching assistant of Toxicology and Preventive Medicine
Professional Service
None
Research Interests
1. The underlying mechanism of heavy metal-induced mitophagy
2. The effect of heavy metals on the DNA damage repair system
1. Fundamental Research Funds for the Central Universities (Program for Excellent Graduate) (lzujbky-2015-227), 2015-2016. The regulatory mechanism of ATM in Lead (Pb)-induced mitophagy. (Host)
2. National Natural Science Foundation of China (31300941), 2014-2016. The regulatory role of ROS and ATM in spermidine-induced mitophagy. (Participate)
Representative Achievements
1. Xueyan Gu, Yongmei Qi*, Zengxiu Feng, Lin Ma, Ke Gao, Yingmei Zhang*. Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway. Toxicol Lett, 2018, 291: 92-100.
2. Yuanzhen Xu1, Xueyan Gu1, Shoujiao Peng, Jianguo Fang, Yingmei Zhang, Dejun Huang, Jianjun Chen*, Kun Gao*. Design, synthesis and biological evaluation of novel sesquiterpene mustards as potential anticancer agents. Eur J Med Chem, 2015, 94: 284-297.
3. Tingting Ge, Jianyuan Han, Yongmei Qi, Xueyan Gu, Lin Ma, Chen Zhang, Sajid Naeem, Dejun Huang*. The toxic effects of chlorophenols and associated mechanisms in fish, Aquat Toxicol, 2017, 184: 78-93.
4. Yongmei Qi1, Qian Qiu1, Xueyan Gu, Yihong Tian, Yingmei Zhang*. ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts, Sci Rep-UK, 2016, 6: 24700.
5. Weiwei Li, Xueyan Gu, Xiaoning Zhang, Jinxin Kong, Nan Ding, Yongmei Qi, Yingmei Zhang, Dejun Huang*. Cadmium delays non-homologous end joining (NHEJ) repair via inhibition of DNA-PKcs phosphorylation and downregulation of XRCC4 and Ligase IV, Mutat Res-Fund Mol M, 2015, 779: 112-123.
6. Zhidan Niu, Wenya Zhang*, Xueyan Gu, Xiaoning Zhang, Yongmei Qi, Yingmei Zhang*. Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells, Environ Toxicol Phar, 2016, 45: 212-221.
7. Xue Wei, Yongmei Qi, Xiaoning Zhang, Xueyan Gu, Hui Cai, Jing Yang, Yingmei Zhang*. ROS act as a upstream signal to mediate cadmium-induced mitophagy in mouse brain, NeuroToxicology, 2015, 46: 19-24.
